GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs2288073 | 1 | rs6708328 | chr2:24412413 | LOC375190 | chr2:24299728-24397519:+ | -0.35 | -8.13 | 3.7E-15 | Venous thromboembolism (SNP x SNP interaction) |
| THCA | cis | rs2288073 | 1 | rs6708328 | chr2:24412413 | POMC | chr2:25383722-25391559:- | -0.21 | -3.58 | 0.00038 | Venous thromboembolism (SNP x SNP interaction) |
| THCA | cis | rs13191362 | 1 | rs67094146 | chr6:163145412 | PACRG | chr6:163148164-163736523:+ | 0.45 | 6.4 | 3.62E-10 | Body mass index |
| THCA | cis | rs60843830 | 1 | rs6709534 | chr2:217334 | SH3YL1 | chr2:218138-264810:- | -0.92 | -25.2 | 8.48E-90 | Spherical equivalent (joint main effects and education interaction) |
| THCA | cis | rs4665809 | 1 | rs6709595 | chr2:26259885 | GPR113 | chr2:26531041-26569685:- | -0.41 | -6.54 | 1.54E-10 | Gut microbiome composition (summer) |
| THCA | cis | rs2274273 | 1 | rs67098772 | chr14:55595242 | KIAA0831 | chr14:55833110-55878576:- | -0.12 | -3.45 | 0.000615 | Protein biomarker |
| THCA | cis | rs9309473 | 1 | rs6710438 | chr2:73820108 | ALMS1P | chr2:73872046-73912692:+ | -0.73 | -11.44 | 5.81E-27 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6710438 | chr2:73820108 | NAT8 | chr2:73867850-73869537:- | -0.4 | -6.25 | 9.05E-10 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6710438 | chr2:73820108 | TPRKB | chr2:73956957-73964517:- | 0.15 | 3.68 | 0.000264 | Metabolite levels |
| THCA | cis | rs12989701 | 1 | rs6710467 | chr2:127889932 | BIN1 | chr2:127805607-127864864:- | -0.29 | -5.38 | 1.17E-7 | Alzheimer's disease (late onset) |
| THCA | cis | rs962856 | 1 | rs6710832 | chr2:67601942 | ETAA1 | chr2:67624442-67637533:+ | -0.18 | -4.29 | 2.18E-5 | Pancreatic cancer |
| THCA | cis | rs4372836 | 1 | rs6710959 | chr2:28958603 | PPP1CB | chr2:28974612-29025805:+ | 0.17 | 4.28 | 2.24E-5 | Body mass index |
| THCA | cis | rs4372836 | 1 | rs6710959 | chr2:28958603 | TRMT61B | chr2:29072690-29093175:- | -0.5 | -10.11 | 6.85E-22 | Body mass index |
| THCA | cis | rs9309473 | 1 | rs6711033 | chr2:73746643 | ALMS1P | chr2:73872046-73912692:+ | 0.72 | 11.08 | 1.5E-25 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6711033 | chr2:73746643 | NAT8 | chr2:73867850-73869537:- | 0.37 | 5.64 | 2.97E-8 | Metabolite levels |